Synlife is innovating around the synthesis and programming of Synthetic Minimal Cells (Synells). Synells contain a biochemical mix of proteins that can transcribe (Tx) and translate (Tl) genes and a DNA program. The Tx/TL mix and DNA is encapsulated in a phospholipid bilayer vesicle called a liposome. Together, these components can reconstitute many of the salient features of living cells.
While much of synthetic biology relies on top-down engineering of extant living systems, this strategy is constrained by the fundamental drives of biology, such as evolutionary pressures and resource utilization for the necessary functions of life.
By BUILDING synthetic minimal cells bottom-up, we can reconstitute desirable functions of biology (e.g. sense-and-respond) without incurring many of its drawbacks.
Programmable cell therapy that is orthogonal to endogenous signals.
Complex, responsive drug delivery for a wide variety of proteins and small molecules.
Detection of low abundance molecular markers.
Generation of RNA reporter molecules followed by deep sequencing.
High-throughput testing of molecular interactions.